Dna helicase pif1
WebGuanine quadruplex (G4) structures are among the most stable secondary DNA structures that can form in vitro, and evidence for their existence in vivo has been steadily accumulating. Originally described mainly for their deleterious effects on genome stability, more recent research has focused on (potential) functions of G4 structures in telomere … WebAmong the enzymes thought to process these structures, the Pif1 DNA helicase is. G-rich sequences found at multiple sites throughout all genomes may form secondary …
Dna helicase pif1
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WebJun 30, 2024 · DNA helicase and polymerase work cooperatively at the replication fork to perform leading-strand DNA synthesis. It was believed that the helicase migrates to the … WebJul 10, 2007 · The PIF1 N-terminal (PINT) domain enhances the interaction with ssDNA through intrinsic binding activity, it also harbors DNA strand-annealing activity. Sequence …
WebOct 17, 2013 · A good candidate DNA helicase is Pif1, an evolutionarily conserved helicase in Saccharomyces cerevisiae important for break-induced replication (BIR) as well as HR-dependent telomere maintenance in the … WebDec 1, 2024 · Pif1 family helicases are 5′ to 3′ DNA helicases in the SF1 superfamily [ 6 ]. The prototype member of this helicase family is the Saccharomyces cerevisiae Pif1 …
WebOct 15, 2024 · Pif1 family helicases have multiple roles in the maintenance of nuclear and mitochondrial DNA in eukaryotes. Saccharomyces cerevisiaePif1 is involved in … WebAmong the enzymes thought to process these structures, the Pif1 DNA helicase is. G-rich sequences found at multiple sites throughout all genomes may form secondary structures called G-quadruplexes (G4), which act as roadblocks for molecular motors. Among the enzymes thought to process these structures, the Pif1 DNA helicase is
WebMar 1, 2016 · Pif1 is a conserved SF1B DNA helicase involved in maintaining genome stability through unwinding double-stranded DNAs (dsDNAs), DNA/RNA hybrids, and G quadruplex (G4) structures. Here, we report the structures of the helicase domain of human Pif1 and Bacteroides sp Pif1 (BaPif1) in complex with ADP- …
drake 350WebDNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. radio uekorheniWebMay 8, 2013 · The S. cerevisiae 5′-to-3′ DNA helicase Pif1 has multiple nuclear functions, including inhibition of telomerase at both telomeres and double-strand breaks 2,3,4,5 and preventing replication ... radio udlaWebSep 19, 2024 · Pif1 family DNA helicases are conserved from bacteria to humans and have critical and diverse functions in vivo that promote genome integrity. Pif1 family helicases share a 23 amino acid region, called the Pif1 signature … drake 3724762WebHelicases are molecular engines which translocate along nucleic acids (NA) to unwind double-strands or remodel NA-protein complexes. While they have an essential role in genome structure and expression, the rules dictating their processivity remain radio u en vivoWebApr 23, 2015 · DOI: 10.1371/journal.pgen.1005186 Abstract Telomerase, the enzyme that maintains telomeres, preferentially lengthens short telomeres. The S. cerevisiae Pif1 DNA helicase inhibits both telomerase-mediated telomere lengthening and de novo telomere addition at double strand breaks (DSB). drake 3724787WebMar 29, 2024 · PIF1 PIF1 5'-to-3' DNA helicase [ (human)] Gene ID: 80119, updated on 8-Dec-2024 Summary This gene encodes a DNA-dependent adenosine triphosphate (ATP)-metabolizing enzyme that functions as a 5' to 3' DNA helicase. The encoded protein can resolve G-quadruplex structures and RNA-DNA hybrids at the ends of chromosomes. drake 35