2024 Klf2 macrophage

Klf2 macrophage

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August undefined, 2024

WebOverexpression of KLF2 protein enhanced the transcription of IL10 and TGFB. On the contrary, site-directed mutagenesis of KLF2 binding site in IL10 and TFGB abrogated luciferase activity in HEK293T cells. Decitabine reduces bone loss in a mouse model of periodontitis by inhibiting osteoclastogenesis through the upregulation of anti … WebMyeloid KLF2 regulates a macrophage-enriched metabolic network and is responsive to metaflammatory stress a Gene-set enrichment analysis of bone marrow-derived macrophages (BMDMs) from...

Klf4, Klf2, and Zfp148 activate autophagy-related genes in smooth ...

WebSep 1, 2009 · Specifically, our studies show that (1) KLF2 inhibits HIF-1 expression and transcriptional activity;(2) altering KLF2 expression affects HIF-lalpha target gene … WebApr 1, 2024 · CE inhibits glycolysis-mediated M1 macrophage polarization by upregulating KLF2 expression in RAW 264.7 macrophages. (a, b) The expression of KLF2 in RAW 264.7 macrophages treated with siRNA control or si-KLF2 was analyzed by western blotting analysis (n = 3). (c, d) Representative photographs and statistical results of PFKFB3, … kenshi where to hire skeletons

Macrophages Arteriosclerosis, Thrombosis, and Vascular Biology

WebApr 25, 2006 · KLF2 Expression Is Reduced with Monocyte Activation/Differentiation into Macrophages. To better understand the role of KLF2 in the regulation of immune cells … WebAug 6, 2014 · As several KLFs promote the anti-inflammatory program in macrophages, we propose that GR and KLFs functionally cooperate to curb inflammation. Electronic supplementary material The online version of this article (doi:10.1186/1471-2164-15-656) contains supplementary material, which is available to authorized users. WebDec 28, 2024 · klf2 klf2 expression in endothelium, but not myocardium, prevents this cardiomyocyte extrusion phenotype. Transcriptome analysis of klf2 mutant hearts reveals that Fgf signaling is affected, and accordingly, we find that inhibition of Fgf signaling in wild-type animals can lead to abluminal cardiomyocyte extrusion. is ifta and irp the same

The role of KLF transcription factor in the regulation of cancer ...

IRF2BP2 Reduces Macrophage Inflammation and …

WebJun 11, 2024 · KLF2 inhibits NF-κB-dependent proinflammatory activation of macrophages ( 56, 57 ). By contrast, KLF6 acts cooperatively with NF-κB to promote proinflammatory … WebApr 2, 2009 · Another particularly interesting example of inconsistency is up regulation of KLF2 observed with PMA/U937 cells on the contrary to M-CSF/macrophages that shows down regulation. KLF2 was previously reported to be down regulated upon monocyte differentiation or activation in THP-1 cells, and has been proved to be a negative regulator … kenshi where to turn in inquisitorsWebOct 31, 2024 · KLF2 alleviates endothelial cell injury and inhibits the formation of THP‑1 macrophage‑derived foam cells by activating Nrf2 and enhancing autophagy Atherosclerosis (AS) is an important cause of common vascular diseases. kenshi where to sell slaves

"WebDec 1, 2014 · Macrophages are the building blocks of intimal atherosclerotic lesions where they scavenge and accumulate modified lipoproteins, profoundly affecting lesion development and progression through their roles in lipid metabolism and as major sensors and effectors of the innate immune system. 1 Lesional macrophages originate from … " - Klf2 macrophage

Klf2 macrophage

JCI - Macrophage plasticity and polarization: in vivo veritas

WebNov 18, 2024 · KLF2 regulates metaflammation transcription in macrophages RNA-sequencing of bone marrow-derived macrophages (BMDMs) isolated from myeloid … WebJun 29, 2024 · Immune-regulatory mechanisms of drug-free remission in rheumatoid arthritis (RA) are unknown. We hypothesized that synovial tissue macrophages (STM), which persist in remission, contribute to ...

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Webmacrophages may account for the increase in atherosclerosis. Remarkably, peritoneal macrophages from KLF2 / mice treated with oxidized LDL demonstrated a 40% increase in lipid uptake when compared to wild-type macrophages (Fig-ure 3A and supplemental Figure IIA). Conversely, adenoviral overexpression of KLF2 in a mouse macrophage cell line WebAdditionally, antiatherogenic properties of KLF2 appear to be mediated through its effects on lymphocyte and monocyte/macrophage biology. KLF2 has important roles in embryonic and adult vasculogenesis and angiogenesis under physiological and pathological conditions and plays a key role in embryonic heart valve formation. Recent data show that ...

WebMay 13, 2024 · The emerging role of KLF2 in regulation of osteoclastic differentiation is examined, specifically in the context of rheumatoid arthritis in which it has been most extensively studied among the musculoskeletal diseases. The therapies that exist to manage diseases associated with osteoclastogenesis are numerous and diverse. WebNational Center for Biotechnology Information

WebMar 1, 2012 · KLF2 regulates macrophage activation by inhibiting NF-κB/HIF-1α activities . IL-4 also induces c-Myc activity in human macrophages , which controls genes of M2 …

WebFeb 5, 2024 · KLF2 is a member of the Kruppel-like transcription factor family of proteins containing highly conserved DNA-binding zinc finger domains. KLF2 participates in the differentiation and regulation of the functional activity of monocytes, T lymphocytes, adipocytes, and vascular endothelial cells. The activity of KLF2 is controlled by several …

WebAug 28, 2008 · KLF2 is a key regulator of endothelial and monocyte/macrophage proinflammatory action. 1,2 In endothelial cells, KLF2 expression is induced by laminar shear stress and inhibited by proinflammatory cytokines. Sustained overexpression of KLF2 results in marked induction of endothelial nitric oxide synthase (eNOS) and thrombomodulin … kenshi where to sell king gurgler headWebKLF2 can also promote the differentiation and function of B-cell through promoting CD62L, CXCR7, and β7-integrins expression [29]. ... has the function of anti-inflammation and anti-thrombotic through regulating the reaction between endothelial cells and macrophages in the case of atherosclerosis via the Ch25h/LXR axis [6], [34]. isiftcls1apps/infydirWebMar 4, 2024 · KLF2 resisted inflammation within macrophages and inhibited M1-type macrophage polarization by recruiting NF-κB cofactors away from the promoters of inflammatory genes . Here, we discovered a novel mechanism involving the inhibition of HSPH1 gene transcription by KLF2 directly binding to its promoter, thus hindering the … kenshi where to settleWebJun 5, 2024 · For isolation of adipose tissue macrophages, adipocytes, and stromal vascular cells (SVCs), adipose tissues isolated from mice were minced into fine pieces immediately after CO 2 asphyxiation and... kenshi where to sell illegal goodsWebMay 1, 2024 · Klf2 Ldlr Lif Lox Lpl Ltbp2 Mmp2 Mmp3 Mmp9 Msr1 Nfkb1 Npy Pdgfa Pdgfb Pdgfrb Plin2 Ppara Ppard Pparg Sele Sell Selp Selplg Serpinb2 Serpine1 Smad3 Smad4 Spp1 Tgfb1 Tgfb2 Tgfbr1 Timp1 Tnc ... Macrophage scavenger receptor 1 Nuclear factor κ B subunit 1 Neuropeptide Y Platelet-derived growth factor subunit A kenshi where to turn in bountyWebApr 1, 2024 · Previous studies have shown that KLF2 is necessary for regulating glycolytic flux. In this study, we overexpressed KLF2 in macrophages to investigate whether KLF2 … is iftar at sunsetWebFeb 5, 2024 · KLF2 binds directly to the promoter of thombomodulin-1, thereby increasing transcription of this potent anti-thrombotic and anti-inflammatory factor ( 8, 15, 16 ). Additionally, KLF2 inhibits the effects of thrombin-mediated endothelial activation by preventing transcription of thrombin’s receptor, PAR-1 ( 17 ). kenshi where to train martial arts