Webpred 15 minútami · Using this approach, we identified a set of genomic loci within the proximal promoter region of significantly down-regulated genes TOPBP1, ZHX2, BCL2L1 and CCR1, which were subsequently analysed using ChIP-qRT-PCR (Additional file 1: Fig. S1). i-BET858 treatment caused minor changes in BRD2, BRD3 and BRD4 enrichment in the … WebOfficial gene symbol, which is typically a short form of the gene name, according to HGNC. TOPBP1 (Dpb11, KIAA0259, TOP2BP1) Protein classi. Assigned HPA protein class (es) for …
TopBP1 deficiency impairs the localization of proteins involved in ...
DNA topoisomerase 2-binding protein 1 (TOPBP1) is a scaffold protein that in humans is encoded by the TOPBP1 gene. TOPBP1 was first identified as a protein binding partner of DNA topoisomerase-IIβ by a yeast 2-hybrid screen, giving it its name. TOPBP1 is involved in a variety of nuclear specific … Zobraziť viac BRCT domains The TOPBP1 gene encodes a scaffold protein which facilitates interactions between different proteins at specific times and locations. It accomplishes these interactions with … Zobraziť viac Cancer Changes in TOPBP1 gene expression are associated with breast cancer, glioblastoma, non-small cell lung cancer, and Zobraziť viac • Yamane K, Tsuruo T (September 1999). "Conserved BRCT regions of TopBP1 and of the tumor suppressor BRCA1 bind strand breaks and termini of DNA". Oncogene. 18 (37): 5194–5203. doi:10.1038/sj.onc.1202922. PMID 10498869. • Mäkiniemi M, … Zobraziť viac DNA damage repair TOPBP1 was first identified as a DNA damage protein through its association with BRCA1, which is a protein heavily implicated in breast cancer pathology. TOPBP1 was found in complex with BRCA1 at sites … Zobraziť viac • DNA damage repair • Ataxia-telangiectasia mutated and RAD3-related (ATR) • BRCA1 Zobraziť viac Web23. dec 2015 · TopBP1 is a multifunctional scaffold protein, which comprises nine BRCT (BRCA1 C-terminus) domains that enable dynamic phospho-dependent protein-protein interactions. 31 The BRCT domains are numbered BRCT0 to BRCT8 counting from the N-terminus. Several mechanisms for recruitment of TopBP1 to stalled replication forks are … cargill stockton plant
TopBP1 promotes malignant progression and correlates with poor …
Web15. jan 2024 · In mammals, TopBP1 is known to play a critical role in the DNA damage response and checkpoint control and is highly expressed in spermatocytes [15,24] via … Web2. aug 2024 · The role of TOPBP1 goes beyond the typical replication stress response; it interacts with the low-complexity nucleolar protein Treacle (also referred to as TCOF1) and forms large Treacle-TOPBP1 foci inside the nucleolus. In response to replication stress, Treacle and TOPBP1 facilitate ATR signaling at stalled replication forks, reinforce ATR ... Web5. máj 2024 · Consequently, hypomethylated TOPBP1 facilitates RAD9 (RADiation sensitive 9) binding and chromatin loading of the TOPBP1-RAD9 complex to fully activate ATR and thus safeguard the genome and protect cells against replication stress. Our study uncovers a demethylation and phosphorylation code that controls the assembly of TOPBP1 … brother hl l2300d driver windows 10